The word that best fits the context of "distress" is suffering, as drug abuse can lead to a wide range of physical, emotional, and psychological harm. While depression, misery, and melancholy are all forms of suffering that drugs can cause or worsen, "suffering" is the broadest term that encompasses the overall negative experience.
Too many drugs are apt to cause 'distress'.
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Question context
This question is part of 🗣️ Verbal Ability within the broader 🧠 Aptitude Mastery subject and appears in the ASF Airports Security Force preparation collection. Reviewing the answer together with nearby questions helps reinforce the underlying concept and identify how it may appear in competitive exams.