Colchicine binds to tubulin, preventing the assembly of spindle fibers. Without spindle fibers, chromosomes cannot align or separate properly during mitosis, which effectively halts cell division at metaphase. So, the inhibition is specifically at the spindle formation stage, not just a mitotic phase like prophase or telophase.
Colchicine inhibits which stage of mitosis?
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This question is part of 🧩 Logical Reasoning within the broader 🧠 Aptitude Mastery subject and appears in the SPSC – Sindh Public Service Commission preparation collection. Reviewing the answer together with nearby questions helps reinforce the underlying concept and identify how it may appear in competitive exams.