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A 38-year-old male present with fatigue, and weight loss. He has long history of recurrent sinusitis, epistaxis and hematuria is found to have haematuria, on urinalysis. He is c=ANCA positive. What is most likely diagnosis?

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A 38-year-old male present with fatigue, and weight loss. He has long history of recurrent sinusitis, epistaxis and hematuria is found to have haematuria, on urinalysis. He is c=ANCA positive. What is most likely diagnosis? Answer: Wegner's granulomatosis

The patient’s presentation of upper respiratory involvement (sinusitis, epistaxis), renal disease (hematuria), constitutional symptoms (fatigue, weight loss), and a positive c-ANCA (anti-proteinase 3 antibody) is classic for Granulomatosis with polyangiitis (Wegener’s granulomatosis).

Question context

This question is part of 🔬 General Science within the broader 🌐 Current Affairs & GK subject and appears in the SPSC – Sindh Public Service Commission preparation collection. Reviewing the answer together with nearby questions helps reinforce the underlying concept and identify how it may appear in competitive exams.